Dynamic remodeling of ESCRT-III


Dynamic remodeling of ESCRT-III
Abscission is executed by a protein machinery named ESCRT-III. It consists of many subunits that form spiral-shaped filaments to constrict the membrane tube connecting the daughter cells until it splits. New findings by the Gerlich lab at IMBA show that ESCRT assemblies are highly dynamic as they rapidly turn over their subunits and that this process is mediated by an enzyme called VPS4.

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